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. 2019 Mar 14;9:4452. doi: 10.1038/s41598-019-41051-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NR5A1 depletion in Sertoli cells impeded testes development. (A) Histological analysis of testis sections stained with Periodic Acid-Schiff in control and SC-SF-1^−/− mice at 6 weeks of age (scale bar = 250 μm). PAS stain showing abnormal phenotype of the seminiferous tubules including vacuolization and visibly large areas of interstitial cells in SC-SF-1^−/− testis. Majority of these seminiferous tubules were devoid of germ cells, forming a Sertoli-cell-only phenotype. Stereomicroscopy images of testes (B) and seminal vesicle (C) from control and SC-SF-1^−/− mice at 6 weeks. Average weight of the testes (D) and seminal vesicles (E) of control and SC-SF-1^−/− mice. The testes were smaller in SC-SF-1^−/− mice, while seminal vesicles were similar in size compared to those of control mice. Values are expressed as the mean ± standard error of the mean (SEM) from 5 mice. *p < 0.001 by two-tailed Student’s unpaired t test. CON = control.