Table 3.
Genome-wide significant CpG sites (P < 10−7) for smoking versus never smoking in lung adenocarcinoma samples.
| CpG | Chr | Position | Annotated Genes | Estimated Difference in % Methylation | Std. Error | P-value | Average % Meth. | Gap Probe |
|---|---|---|---|---|---|---|---|---|
| Current Smoking | ||||||||
| cg12086028 | chr6 | 33241026 | VPS52; RPS18 | −15.12 | 2.37 | 5.53E-10 | 31.5 | N |
| cg27033919 | chr11 | 62622173 | SNORD30; SNORD29; SLC3A2; SNORD31; SNORD28; SNHG1 | −13.19 | 2.16 | 2.79E-09 | 13.4 | Y |
| cg18806997 | chr1 | 45242078 | SNORD46; RPS8; SNORD38A | −7.2 | 1.19 | 3.34E-09 | 9.6 | N |
| cg22132788 | chr7 | 45002486 | MYO1G | 13.31 | 2.24 | 7.16E-09 | 76.3 | N |
| cg16290996 | chr1 | 173835989 | GAS5; SNORD78; SNORD76; SNORD77; SNORD44; SNORD79 | −12.64 | 2.13 | 7.26E-09 | 21.8 | N |
| cg13985198 | chr1 | 45242073 | SNORD46; RPS8; SNORD38A | −8.22 | 1.39 | 7.63E-09 | 6 | Y |
| cg02607319 | chr7 | 45002112 | 12.95 | 2.23 | 1.36E-08 | 69.2 | N | |
| cg07362537 | chr6 | 33240820 | VPS52; RPS18 | −13.18 | 2.35 | 3.96E-08 | 21.2 | Y |
| cg02905828 | chr11 | 62622234 | SNORD30; SNORD29; SLC3A2; SNORD31; SNORD28; SNHG1 | −13.25 | 2.37 | 4.36E-08 | 16.5 | N |
| cg11374355 | chr19 | 39925660 | RPS16 | −9.26 | 1.66 | 5.27E-08 | 42.1 | N |
| cg12973930 | chr19 | 57049695 | ZFP28 | −10.66 | 1.92 | 5.73E-08 | 11.5 | N |
| cg19089201 | chr7 | 45002287 | MYO1G | 11.88 | 2.16 | 7.42E-08 | 68 | N |
| cg09345320 | chr11 | 62622179 | SNORD30; SNORD29; SLC3A2; SNORD31; SNORD28; SNHG1 | −13.27 | 2.43 | 8.39E-08 | 13 | Y |
| cg05840553 | chr9 | 130212635 | RPL12; LRSAM1; LRSAM1 | −6.28 | 1.15 | 8.52E-08 | 6.8 | Y |
| Former Smoking (≤15 Years) | ||||||||
| cg22132788 | chr7 | 45002486 | MYO1G | 15.03 | 2.05 | 1.57E-12 | 76.3 | N |
| cg02607319 | chr7 | 45002112 | 14.79 | 2.03 | 2.31E-12 | 69.2 | N | |
| cg19089201 | chr7 | 45002287 | MYO1G | 13.17 | 1.97 | 9.73E-11 | 68 | N |
| cg04180046 | chr7 | 45002736 | MYO1G | 12.01 | 1.91 | 1.03E-09 | 57.8 | N |
| cg23160522 | chr15 | 75015787 | CYP1A1 | −8.68 | 1.44 | 4.34E-09 | 57.9 | N |
| cg18806997 | chr1 | 45242078 | SNORD46; RPS8; SNORD38A | −6.12 | 1.08 | 3.34E-08 | 9.6 | N |
| cg13985198 | chr1 | 45242073 | SNORD46; RPS8; SNORD38A | −7.14 | 1.27 | 3.69E-08 | 6 | Y |
| cg18092474 | chr15 | 75019302 | CYP1A1 | −12.32 | 2.21 | 4.65E-08 | 43.6 | N |
| cg01410359 | chr2 | 38302230 | CYP1B1 | −10.14 | 1.82 | 4.66E-08 | 33.5 | N |
| cg03224163 | chr7 | 139420300 | HIPK2 | −3.89 | 0.7 | 6.01E-08 | 83.1 | Y |
| cg09799983 | chr2 | 38301756 | CYP1B1 | −23.47 | 4.25 | 6.59E-08 | 39.3 | N |
| cg12803068 | chr7 | 45002919 | MYO1G | 9.37 | 1.72 | 9.84E-08 | 73.4 | N |
| Former Smoking (>15 Years) | ||||||||
| cg25157280 | chr3 | 48700498 | CELSR3 | −8.97 | 1.57 | 2.27E-08 | 5.9 | N |
| cg22132788 | chr7 | 45002486 | MYO1G | 11.88 | 2.17 | 8.43E-08 | 76.3 | N |
| cg09736162 | chr3 | 48700443 | CELSR3 | −9.35 | 1.71 | 9.34E-08 | 9.1 | N |