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. 2019 Mar 14;2:100. doi: 10.1038/s42003-019-0341-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Relationships of sperm methylation alterations associated with gestation length, sire calving ease (SCE), body depth (BDE), cow conception rate (CCR). a Intersections between differentially methylated regions (DMRs) of gestation length and DMRs of SCE, BDE and CCR, respectively. P-value is calculated using a Fisher-exact test. b KEGG pathway functional enrichment of genes that are overlapped with shared DMRs in gestation length & SCE, gestation length & BDE, and gestation length & CCR, respectively. c Frequency of shared DMRs with the same (+) or opposite (−) change directions in gestation length & SCE, gestation length & BDE, and gestation length & CCR, respectively. d Comparisons of genetic correlations of gestation length & SCE, gestation length & BDE, and gestation length & CCR within their shared DMRs of same (+) or opposite (−) change directions, and over the entire genome (O), respectively