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. 2019 Mar 14;9:4423. doi: 10.1038/s41598-019-40986-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional CEST simulation results. The expected CEST-fMRI contrasts for the acquisition and reconstruction strategy adopted in this study, based on S(−1.2 ppm)/S(+1.2 ppm) signal ratio calculations plotted along the y-axis, are correlated against various potential variables: water T₂*, glucose concentration, glycogen concentration, glutamate concentration, MT effects, glucose T₂ and susceptibility changes. The colors were chosen according to the maximum expected relative changes (shown in %); note that a change in glucose’s exchange rate will also affect the obtained contrasts.