Figure 6.

GlucoCEST-fMRI acquisition strategy. (a) In vivo Z-spectrum acquired from an 8-mm³ STEAM voxel placed in the somatosensory cortex of a rat brain (0.2-ppm step, 2 s/1.5 µT RF saturation). (b) Four-block timing sequences showing the stimulation paradigm, the conventional BOLD fMRI approach and the glucoCEST-fMRI data collecting strategy based on the consecutive acquisition of +1.2 ppm (red) and −1.2 ppm (blue) CEST images. Note the change in the acquisition order every two blocks in order to improve the BOLD compensation mechanism.