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. 2019 Mar 14;9:4574. doi: 10.1038/s41598-019-39824-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of tongue tumor on Low Threshold A-Slow- Mechanoreceptors of lingual afferents. Normal and tumor-bearing preparations at day 9 post HSC2 inoculation were evaluated for mechanical responses of A-slow -LTMR fibers. (a) Impulses of A-slow -LTMR fibers from normal and tumor-bearing preparations to sustained mechanical forces. Data are presented as mean ± SEM. Data are analyzed with one-way ANOVA with Bonferroni post hoc test at p < 0.05. n = 13 fibers in normal group and n = 17 fibers in tumor group. (b) von Frey Thresholds of A-slow -LTMR fibers from normal and tumor group. Data are presented as mean ± SEM. Data are analyzed with Mann Whitney U test at p < 0.05. (c) Conduction velocity of A-slow -LTMR fibers from normal and tumor group. Data are presented as mean ± SEM. Data are analyzed with unpaired t-test at p < 0.05. (d,e) Representative traces for normal and tumor groups showing A-slow -LTMR fiber responses upon sustained mechanical forces. Numbers in red indicate number of impulses per force applied. (f) Table lists the number of A-slow -LTMR fibers tested, mean conduction velocities (CV) and mean von Frey thresholds for both groups.