Table 1.
Measured blood parameters 8 months after Cul3 disruption.
| Blood Parameters | CTRL | KS-Cul3−/− | P value |
|---|---|---|---|
| Sodium (mmol/L) | 146 ± 0.2 | 153 ± 1.8 | 0.001 |
| Potassium (mmol/L) | 4.2 ± 0.1 | 5.9 ± 0.5 | 0.003 |
| Chloride (mmol/L) | 111 ± 0.9 | 109 ± 1.1 | 0.147 |
| Ionized Calcium (mmol/L) | 1.3 ± 0 | 1.1 ± 0 | 0.006 |
| Total Carbon Dioxide (mmol/L) | 23 ± 1.5 | 28 ± 0.6 | 0.027 |
| Blood Urea Nitrogen (mg/dL) | 22 ± 1.5 | 129 ± 11.2 | 0.001 |
| Creatinine (mg/dL) | 0.2 ± 0 | 0.8 ± 0.1 | 0.001 |
| Hematocrit (% PCV) | 35 ± 1.7 | 22 ± 2.7 | 0.001 |
| Hemaglobin (g/dL) | 11.9 ± 0.6 | 7.4 ± 0.9 | 0.001 |
| Anion Gap (mmol/L) | 17 ± 1.1 | 21 ± 0.9 | 0.218 |
| Body weight (g) | 30.1 ± 1.9 | 16.8 ± 1.2 | 0.001 |
KS-Cul3−/− mice display CKD phenotype. Hyperkalemia, renal failure, anemia and other abnormal blood values 8 months after Cul3 deletion. Data represent the mean ± SEM. P values were calculated by unpaired, two-tailed, t test obtained from 8 CTRL vs. 5 KS-Cul3−/− mice.