Table 2.
Results of the pathway enrichment analysis showing significant pathways*.
| Analysis | Pathway | Total metabs in pathway | #sig. metabs in pathway | Raw p | FDR adjusted p | |
|---|---|---|---|---|---|---|
| Group | Rhythmic | Phenylalanine and tyrosine metabolism | 13 | 4 | 0.000623 | 0.0492 |
| Linear | — | — | — | — | — | |
| Individual | Rhythmic | Citric acid cycle | 23 | 9 | 0.000107 | 0.0085 |
| Urea cycle | 20 | 8 | 0.000226 | 0.00892 | ||
| Linear | Citric acid cycle | 23 | 10 | 2.41E-06 | 0.00019 | |
| Urea cycle | 20 | 8 | 5.83E-05 | 0.0023 | ||
| Malate-aspartate shuttle | 8 | 4 | 0.00195 | 0.0337 | ||
| Beta-alanine metabolism | 13 | 5 | 0.00207 | 0.0337 | ||
| Galactose metabolism | 25 | 7 | 0.00213 | 0.0337 | ||
*Only metabolic pathways that were significant following FDR correction are shown. The total number of metabolites in the pathway, the number of significant metabolites in the pathway and the raw and FDR adjusted p-values are shown for each pathway. The full results of the pathway enrichment analysis are shown in SI Tables 6–9 and Figs 3–6.