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. 2019 Mar 14;9:4599. doi: 10.1038/s41598-018-37622-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of KIF4A, 9, 18A, and 23 on survival in GBM patients. The cutoff value determination in Cutoff Finder was based on survival, with significance based on the log-rank test for patient outcome (http://molpath.charite.de/cutoff/assign.jsp). (A) High mRNA expression of KIF4A was significantly associated with poor prognosis (HR: 1.36 [95% CI: 1.02–1.82]). In histograms of KIF9 mRNA expression, vertical red lines designate 0.4256 as the optimal cutoffs of mRNA derived from the log-rank test. (B) High mRNA expression of KIF18A was significantly associated with poor prognosis (HR: 1.38 [95% CI 1.02–1.87]). In histograms of KIF9 mRNA expression, vertical red lines designate 0.1041 as the optimal cutoffs of mRNA derived from the log-rank test. (C) High mRNA expression of KIF23 was significantly associated with poor prognosis (HR: 1.31 [95% CI: 1.05–1.62]). In histograms of KIF9 mRNA expression, vertical red lines designate 0.2015 as the optimal cutoffs of mRNA derived from the log-rank test. (D) High mRNA expression of KIF9 was significantly associated with poor prognosis (HR: 2.53 [95% CI: 1.61–3.99]). In histograms of KIF9 mRNA expression, vertical red lines designate 5.233 as the optimal cutoffs of mRNA derived from the log-rank test.