Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 14;9:4599. doi: 10.1038/s41598-018-37622-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Network analysis and GSEA based on hallmark gene sets in LGG. The graph displays the enrichment gene set based on the pathway-provided hallmark genes in the top 10% vs. bottom 10% groups of KIF4A, 9, 18A, and 23 in LGG. (A,D,E) Pathways of the G₂M checkpoint, E2F targets, mitotic spindle, and Myc targets v1 were increased in the high KIF4A, 18A, and 23 groups, which showed adverse effects on prognosis. (B) Pathways of EMT and angiogenesis were increased, and pathways of the mitotic spindle and G₂M checkpoint were decreased in the high-KIF9 groups. (C) Network analysis of KIF4A, 9, 18A, and 23 in LGG was performed in cBioportal (http://www.cbioportal.org/)^21,22. Each gene in the network is marked with a circle. Linkages related to state change, transport, phosphorylation, complex, neighbor among genes were connected by color lines.