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. 2019 Mar 14;9:4603. doi: 10.1038/s41598-019-40922-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional classification of genes in Msal^T, Msal-like^CCUG64054, Mche^T and Mabs^ATCC19977 into subsystem as indicated. (a) Subsystem classification of 2173 core genes using Msal^T. Of note, that a gene can be classified in more than one subsystem. (b) Subsystem classification of specific genes present in Mfra^CCUG64054 and Mabs^ATCC19977, and present in Msal^T and Mche^T as indictated. (c) Classification of unique genes present in Mabs^ATCC19977, Mche^T, Msal^T and Msal-like^CCUG64054 in the subsystem “Virulence, Disease and Defence”. (d) Subsystem classification of mutational hotspot genes in Msal, see main text for details.