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. 2019 Mar 14;9:4481. doi: 10.1038/s41598-019-40812-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genetic composition of H. influenzae and H. parainfluenzae capsular operons. Genes marked in dark grey belong to region I, while those from region III are marked in light grey. The sequences of H. influenzae serotypes c and d are not available on NCBI (genes represented by white dots in region I and genes represented by white stripes in region III). The ccsD gene represented by black dots has a 1-bp deletion, resulting in an interrupted gene. In the HUB11505 strain, pcsB is interrupted by a transposase, but there is an alternative ORF that has 471 fewer bp than that of HUB12435, HUB12445 and HUB12640. 1. ascD. 2. ecsF.