. 2019 Mar 14;9:4541. doi: 10.1038/s41598-019-40866-2

Table 3.

Mechanism study of Furanodiene in zebrafish models (Mean ± SE).

Assays	Biomarkers	Efficacy (%)
Assays	Biomarkers	1.4 μM	4.1 μM	12.2 μM
Antiangiogenesis	SIVs inhibition	19 ± 2.19	21 ± 2.33^*	43 ± 3.55^**
Apoptosis	AO staining	20 ± 3.29	51 ± 2.31^***	65 ± 0.99^***
	caspase-3/7	2 ± 1.78	16 ± 1.47^*	67 ± 1.66^***
	caspase-8	11 ± 1.56	17 ± 1.46^*	68 ± 2.17^***
	caspase-9	8 ± 1.69	17 ± 2.31^*	69 ± 2.85^***
Comet assay	Single stranded DNA strand fracture analysis	116 ± 3.58	370 ± 2.45^**	540 ± 3.97^***
Comet assay	Double stranded DNA strand fracture analysis	118 ± 2.79	143 ± 3.12^**	208 ± 2.25^***
ROS	ROS production	145 ± 1.56	190 ± 3.18^*	521 ± 3.98^***
P-glycoprotein	Pgp inhibition	21 ± 1.88^*	34 ± 2.05^*	58 ± 1.82^*

Compared with control: *p < 0.05, **p < 0.01 and ***p < 0.001.