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. 2019 Mar 14;9:4541. doi: 10.1038/s41598-019-40866-2

Table 3.

Mechanism study of Furanodiene in zebrafish models (Mean ± SE).

Assays Biomarkers Efficacy (%)
1.4 μM 4.1 μM 12.2 μM
Antiangiogenesis SIVs inhibition 19 ± 2.19 21 ± 2.33* 43 ± 3.55**
Apoptosis AO staining 20 ± 3.29 51 ± 2.31*** 65 ± 0.99***
caspase-3/7 2 ± 1.78 16 ± 1.47* 67 ± 1.66***
caspase-8 11 ± 1.56 17 ± 1.46* 68 ± 2.17***
caspase-9 8 ± 1.69 17 ± 2.31* 69 ± 2.85***
Comet assay Single stranded DNA strand fracture analysis 116 ± 3.58 370 ± 2.45** 540 ± 3.97***
Double stranded DNA strand fracture analysis 118 ± 2.79 143 ± 3.12** 208 ± 2.25***
ROS ROS production 145 ± 1.56 190 ± 3.18* 521 ± 3.98***
P-glycoprotein Pgp inhibition 21 ± 1.88* 34 ± 2.05* 58 ± 1.82*

Compared with control: *p < 0.05, **p < 0.01 and ***p < 0.001.