Figure 1.

Phylogenetic tree of biogenic amine receptors in Ae. aegypti, An. gambiae and D. melanogaster. The rooted phylogenetic tree was built with putative 5-HT receptor and other biogenic amine receptor amino acid sequences in Ae. aegypti (AAEL), An. gambiae (AGAP), and D. melanogaster (Dro) species; the An. gambiae Adipokinetic Hormone receptor was the outgroup. Receptors are denoted only by their unique accession number. The blue, red, and green clusters represent the various 5-HT subfamilies; the blue includes proteins most similar to the 5-HT₁ subfamily, while the red and green encompass those grouped into the 5-HT₂ and 5-HT₇ subfamilies, respectively.