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. 2019 Mar 14;9:4418. doi: 10.1038/s41598-019-40988-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Skewed distribution of platelet size in patients. The vertical axis represents the estimated cross-sectional area [μm²]. The horizontal dotted line represents the cut-off value (12.6 μm²) of the estimated cross-sectional area for macrothrombocytes. Note that the distributions of platelet size were skewed positively (upwards) in patients 1–3. Macrothrombocytes comprised none (1/120) of the platelets in the control, 34.8% (47/135) of the platelets in patient 1, 27.2% (24/88) of the platelets in patient 2, and 36.4% (51/140) of the platelets in patient 3.