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. 2019 Mar 14;9:4588. doi: 10.1038/s41598-019-40964-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Clinical investigation of B6 mice following intraspinal TMEV infection. TMEV-infected mice showed significant clinical signs (A, starting at 11 dpi) and a deterioration of motor coordination and performance (B, starting at 7 dpi) compared to mock infected animals. The following number of animals was evaluated per group: n = 25–26 from 0 to 3 dpi; n = 17–20 from 4 to 7 dpi; n = 12–14 from 8 to 28 dpi. The graphs show mean (solid line) and individual value plots indicating the clinical score of each animal consisting of the sum of scores in the categories posture and external appearance, behaviour and activity as well as gait for clinical investigation or a mean round per minute value of three consecutive measurements for rotarod analysis, respectively. Significant differences between the groups as detected by Mann-Whitney U-test are marked by asterisks (p ≤ 0.05).