Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 14;9:4518. doi: 10.1038/s41598-019-41241-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Specific calcium signal in hippocampus and EC. (A) Four kinds of calcium activities in hippocampal CA1. The amplitudes of these four kinds of calcium signals were as follows. Before KA: 0.65 ± 0.04% ∆F/F, wave1: 4.25 ± 0.35% ∆F/F, wave2: 11.83 ± 1.21% ∆F/F, slow flash: 4.03 ± 0.32% ∆F/F; before vs. wave1, ***p = 0.0001; before vs. wave2, ***p = 0.0002; before vs. slow flash, ***p = 0.0002; wave1 vs. wave2, *p = 0.0031; wave2 and slow flash, **p = 0.0014; n = 4 mice, Paired t-tests. The occurrence rates were as follows. Wave1: 1.06 ± 0.06 Hz, wave2: 1.66 ± 0.14 Hz, slow flash: 0.28 ± 0.03 Hz; wave1 vs. wave2, *p = 0.0108; wave1 vs. slow flash, ****p < 0.0001; wave2 vs. slow flash, ***p = 0.0002; n = 4 mice, Paired t-tests. (B) Three kinds of calcium activities in hippocampal CA3. The amplitudes of these three kinds of calcium signals were as follows. Before KA: 0.54 ± 0.11% ∆F/F, wave1: 2.86 ± 0.64% ∆F/F, wave2: 7.73 ± 1.45% ∆F/F; before vs. wave1, *p = 0.0148; before vs. wave2, **p = 0.0043; wave1 vs. wave2: *p = 0.02; n = 4 mice, Paired t-tests. The occurrence rates were as follows. Wave1: 0.92 ± 0.07 Hz, wave2: 1.68 ± 0.19 Hz; wave1 vs. wave2, *p = 0.0329; n = 4 mice, Paired t-tests. (C) Three kinds of calcium activities in hippocampal DG. The amplitudes of these three kinds of calcium signals were as follows. Before KA: 0.61 ± 0.04% ∆F/F, wave1: 1.53 ± 0.21 ∆F/F, wave2: 15.63 ± 2.04% ∆F/F; before vs. wave1, *p = 0.018; before vs. wave2, **p = 0.006; wave1 vs. wave2: **p = 0.0077; n = 4 mice, Paired t-tests. The occurrence rates were as follows. Wave1: 1.27 ± 0.13 Hz, wave2: 1.68 ± 0.54 Hz; wave1 vs. wave2, p = 0.51; n = 4 mice, Paired t-tests. (D) Two kinds of calcium activities in EC. The amplitudes of these two kinds of calcium signals were as follows. Before KA: 1.04 ± 0.05% ∆F/F, wave1: 4.15 ± 0.37% ∆F/F; before vs. wave1, ***p = 0.0009; n = 5 mice, Paired t-tests. And the occurrence rate of wave1 was 1.31 ± 0.29 Hz. Wave2 was divided into two parts, namely build-up (blue box) and CSD-like wave (grey box).