Table 3.
Relationships between IL1R2 and IL1R1polymorphism and ONFH risk
| SNP | Model | Genotype | Control | Case | Before adjusted | After adjusted | AIC | BIC | ||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p avalue | OR (95% CI) | p bvalue | |||||||
| rs11674595 | Codominant | T/T | 269 (61.3%) | 147 (51.4%) | 1 | 0.03 | 1 | 0.033 | 971.5 | 985.3 |
| C/T | 155 (35.3%) | 125 (43.7%) | 1.48 (1.08–2.01) | 1.49 (1.09–2.03) | ||||||
| C/C | 15 (3.4%) | 14 (4.9%) | 1.71 (0.80–3.64) | 1.60 (0.75–3.42) | ||||||
| Dominant | T/T | 269 (61.3%) | 147 (51.4%) | 1 | 0.009 | 1 | 0.009 | 969.6 | 978.8 | |
| C/T‐C/C | 170 (38.7%) | 139 (48.6%) | 1.50 (1.11‐2.02) | 1.50 (1.10–2.03) | ||||||
| Recessive | T/T‐C/T | 424 (96.6%) | 272 (95.1%) | 1 | 0.33 | 1 | 0.420 | 975.6 | 984.7 | |
| C/C | 15 (3.4%) | 14 (4.9%) | 1.45 (0.69–3.06) | 1.36 (0.64–2.88) | ||||||
| Log‐additive | – | – | – | 1.41 (1.09–1.83) | 0.01 | 1.40 (1.08–1.81) | 0.012 | 969.8 | 979 | |
| rs10490571 | Codominant | C/C | 310 (70.5%) | 172 (60.1%) | 1 | 0.005 | 1 | 0.006 | 969.1 | 982.9 |
| C/T | 112 (25.4%) | 105 (36.7%) | 1.69 (1.22–2.34) | 1.69 (1.22–2.34) | ||||||
| T/T | 18 (4.1%) | 9 (3.1%) | 0.90 (0.40–2.05) | 0.88 (0.39–2.01) | ||||||
| Dominant | C/C | 310 (70.5%) | 172 (60.1%) | 1 | 0.004 | 1 | 0.005 | 969.3 | 978.5 | |
| C/T‐T/T | 130 (29.6%) | 114 (39.9%) | 1.58 (1.16–2.16) | 1.57 (1.15–2.16) | ||||||
| Recessive | C/C‐C/T | 422 (95.9%) | 277 (96.8%) | 1 | 0.51 | 1 | 0.470 | 977.1 | 986.3 | |
| T/T | 18 (4.1%) | 9 (3.1%) | 0.76 (0.34–1.72) | 0.74 (0.33–1.69) | ||||||
| Log‐additive | – | – | – | 1.35 (1.03–1.76) | 0.027 | 1.34 (1.03–1.75) | 0.031 | 972.6 | 981.8 | |
| rs3917225 | Codominant | A/A | 196 (44.5%) | 98 (34.4%) | 1 | 0.02 | 1 | 0.022 | 969.9 | 983.6 |
| A/G | 182 (41.4%) | 135 (47.4%) | 1.48 (1.07–2.06) | 1.50 (1.07–2.09) | ||||||
| G/G | 62 (14.1%) | 52 (18.2%) | 1.68 (1.08–2.61) | 1.65 (1.06–2.58) | ||||||
| Dominant | A/A | 196 (44.5%) | 98 (34.4%) | 1 | 0.006 | 1 | 0.007 | 968.2 | 977.4 | |
| A/G‐G/G | 244 (55.5%) | 187 (65.6%) | 1.53 (1.13–2.09) | 1.54 (1.13–2.10) | ||||||
| Recessive | A/A‐A/G | 378 (85.9%) | 233 (81.8%) | 1 | 0.14 | 1 | 0.170 | 973.4 | 982.6 | |
| G/G | 62 (14.1%) | 52 (18.2%) | 1.36 (0.91–2.04) | 1.33 (0.89–2.00) | ||||||
| Log‐additive | – | – | – | 1.33 (1.08–1.64) | 0.008 | 1.32 (1.07–1.64) | 0.009 | 968.6 | 977.8 | |
SNP: single‐nucleotide polymorphism; OR: odds ratio; 95% CI: 95% confidence interval.
a
p‐values were calculated from unconditional logistic regression analysis.
b
p‐values were calculated by unconditional logistic regression analysis with adjustments for age and gender.
The bold values and p ≤ 0.05 indicate statistical significance.