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. 2019 Mar 15;39(3):BSR20181937. doi: 10.1042/BSR20181937

Figure 3. TP73-AS1 regulates the metastasis of pancreatic cancer cells through miR-141.

Figure 3

(A) Prediction of binding sites between TP73-AS1 and miR-141; Luciferase reporter assays demonstrated that miR-141 mimics significantly decreased the luciferase activity of TP73-AS1 WT HEK293T cells but did not affect that of TP73-AS1 MUT. (B) Knockdown of TP73-AS1 in pancreatic cancer cells significantly increased the miR-141 expression. (C) TP73-AS1 was not significantly changed by the transfection of the miR-141 inhibitor in pancreatic cancer cells. (D) MiR-141 expression was down-regulated by the transfection of the miR-141 inhibitor in pancreatic cancer cells. (E) MiR-141 was significantly lower in pancreatic cancer tissue than in the adjacent normal tissue. (F and G) Migration (F) and invasion (G) assays for pancreatic cancer cells transfected with siTP73-AS1 in the presence of the miR-141 inhibitor or negative control; ***P<0.001.