Table 7. Influence of AP-2α and AP-2γ factors on selected developmental processes, diseases, and interactive molecules (based on GeneCards, Reactome databases, and Atlas of Genetics and Cytogenetics in Oncology and Haematology).

	AP-2α	AP-2γ
Participation in development processess – major	Face, eye, limb, body wall, neural tube development
Participation in development processess – other	Early morphogenesis of lens vesicle; kidney development	Male gonad development
Associated diseases	BOFS; ectopic thymus; anophthalmia-microphthalmia syndrome	Exencephaly; melanoma; pre-eclampsia
Mutual interactions	Interacts with WWOX, CITED2, CITED4, UBE2I, KCTD1, KCTD15, EP300; Suppresses MCAM/MUC18, C/EBPα; Stimulates transcriptional activation of PITX2
Exclusive interactions	Along with binding NPM1 – represses HSPD1 gene expression, inhibiting formation of mitochondrial chaperonin;	Along with MTA1 – mediates epigenetic regulation of ESR1 expression in breast cancer (BCa); Interacts with KDM5B
	Stimulates APOE gene transcription in co-operation with DEK;
	Interacts with RALBP1 (in complex containing NUMB and EPN1) during interphase and mitosis