Figure 2. Schematic diagram of representative SNXs involved in the trafficking pathways of cargoes.

Different transmembrane proteins, termed as cargoes, are internalized into early endosomes from the plasma membrane via the endocytosis process. Then, retromer mediates some cargo recycling to the trans-Golgi network or back to the plasma membrane. On the other side, maturation of early endosomes into late endosomes leads to cargo degradation via lysosome. Representative SNXs are shown in the different trafficking routes of cargoes. SNX, sorting nexin; trans-Golgi network, TGN.