Figure 4.
(a) The sequence of the 3′‐untranslated region (3′‐UTR) of the HIF‐1α mRNA and the microRNA‐186 (miR‐186) binding site. (b) Bioinformatics and luciferase reporter assay results. MiR‐186 significantly decreased the relative luciferase activity of the wild‐type HIF‐1α 3‐UTR compared with the mutant HIF‐1α 3′‐UTR