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(a) Distribution of COL1A1 1 and COL1A2 2 mutations for de novo and inherited osteogenesis imperfecta (OI). (b) Functional types of mutations in de novo and inherited OI. (c) Collagen defect distributions in de novo and inherited OI. 1 COL1A1 GenBank reference sequence (gDNA NG_007400.1, cDNA NM_000088.3). 2 COL1A2 GenBank reference sequence (gDNA NG_007405.1, cDNA NM_000089.3)
