Sancho‐Cuesta 1993.

Methods	Randomised controlled trial
Participants	Patients with advanced cancer, anorexia and weight loss
Interventions	50 patients MA 160 mg daily versus 50 patients 320 mg daily for 24 weeks
Outcomes	Weight gain, side effects
Notes	Loss to follow‐up not described Cachexia was not defined QS: 1
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information to permit judgement of low risk or high risk
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement of low risk or high risk
Blinding (performance bias and detection bias) All outcomes	Low risk	This study was not blinded
Blinding of participants and personnel (performance bias) All outcomes	Low risk	The main outcome was weight. This is not a blinded study but the main outcome is not likely to be influenced by lack of blinding.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	This is not a blinded study but the main outcome is not likely to be influenced by lack of blinding
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Loss to follow‐up not described
Selective reporting (reporting bias)	Low risk	All the outcomes described in the study were reported
Other bias	Unclear risk	Report only from old conference proceeding