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. 2019 Feb 27;3(5):724–728. doi: 10.1182/bloodadvances.2018018895

Figure 2.

Figure 2.

Upon LPS challenge in mice, nucleosomes are derived from both hematopoietic and nonhematopoietic cells. Plasma nucleosomes (A) and MPO (B) levels after intraperitoneal injection of LPS in mice; n = 8 per group. (C) The ratio of nucleosomes vs MPO in LPS-challenged mice. (D) Model of male/female mixed bone marrow chimera mice. General IL-3 gene PCR (E) and specific SRY PCR (F) on extracellular DNA before and 6 and 20 hours after LPS challenge in male/female mixed chimera mice. Pre-LPS (●), n = 1-2 per group; 6 hours after LPS (▪), n = 4-7; and 20 hours after LPS (▲), n = 5-7. Data are presented as mean ± standard error. P < .05 was considered significant. *P < .05, **P < .01, ***P < .001, ****P < .0001.