Table 3.
Adjusted coefficient of determination (R2) obtained by the kinetic evaluation of drug release plots and calculation of lag time. (n) The Korsmeyer-Peppas exponent of the release mechanism; (b) shape parameter of Weibull model.
| Kinetic Model | Parameters | OA1 | OA2 | OAP1 | OAP2 | P1 | P2 | IM1 | IM2 |
|---|---|---|---|---|---|---|---|---|---|
| Lag time (h) | 2.56 | 3.21 | 3.33 | 3.10 | 3.24 | 3.37 | 3.68 | 3.66 | |
| Baker-Lonsdale | R2 | 0.77 | 0.00 | 0.77 | 0.78 | 0.77 | 0.77 | 0.76 | 0.75 |
| First order | R2 | 0.96 | 0.97 | 0.96 | 0.91 | 0.96 | 0.96 | 0.96 | 0.95 |
| Higuchi | R2 | 0.77 | 0.78 | 0.78 | 0.79 | 0.77 | 0.77 | 0.76 | 0.75 |
| Hixson-Crowell | R2 | 0.96 | 0.97 | 0.97 | 0.90 | 0.96 | 0.96 | 0.96 | 0.96 |
| Korsmeyer-Peppas | R2 | 0.99 | 1.00 | 0.99 | 0.99 | 0.99 | 0.99 | 1.00 | 0.99 |
| n | 1.67 | 1.34 | 1.36 | 1.74 | 1.82 | 1.74 | 1.81 | 1.58 | |
| Weibull | R2 | 1.00 | 1.00 | 1.00 | 0.99 | 0.99 | 1.00 | 1.00 | 0.99 |
| b | 1.37 | 1.20 | 1.17 | 5.6 | 1.50 | 1.17 | 2.22 | 1.73 |