Figure 48.

One-pot synthesis of cylindrical brush copolypeptides reported by Deming et al. The N-carboxyanhydride (NCA) component (blue) of N^ε-(alloc-l-methionyl)-l-lysine NCA was first polymerized using (PMe₃)₄Co initiator to give a linear polypeptide that bears pendant initiator precursors (green). Side-chain initiators were then activated by using dmpeNi(COD), followed by addition of a second NCA monomer (red) to give the brush copolymers. Reproduced with permission from reference [218].