Figure 7.
iNOS inhibition reduced food intake and weight gain in HFF mice
A, energy intake during 24 h after l‐NIL injection (10 mg kg−1) was significantly reduced compared to saline treatment in HFF mice (P < 0.05, two‐way ANOVA with Bonferroni test, N = 7). B, no significant alteration in meal size was observed. C, inter‐meal interval was increased by l‐NIL in HFF mice (P < 0.05, two‐way ANOVA with Bonferroni test). D–F, HFF mice were treated with l‐NIL (10 mg kg−1, daily i.p. injection) or saline for 3 weeks. l‐NIL reduced body weight gain (D) (P < 0.05, unpaired t test, N = 8) and energy intake (E) (P < 0.05) in the first week of treatment. Percentage of epididymal fat was lower in l‐NIL treated mice (F) (P < 0.05).