Figure 1.

Cladogram of human CCC family members
The tree was generated with Clustal Omega and FigTree v1.4.3. Amino acid sequences included in the phylogenetic analysis were from the most abundant CCC variants in human. Accession numbers used: NKCC1, NP_001037.1; NKCC2, NP_000329.2; NCC, NP_000330.2; KCC1, NP_005063.1; KCC2, NP_001128243.1; KCC3, NP_598408.1; KCC4, NP_006589.2; CCC8, NP_064631.2; CCC9, NP_078904.3.