Kainate receptors activated by 0.1 μm KA modulate IPSCs
A, plot of voltage–current curve for a cell at t = 0 (E
GABA = −65.6 mV) and t = 15 (E
GABA = −74.6 mV). Inset: examples of evoked IPSCs (scale bar = 60 pA, 10 ms). B, group data showing E
GABA at t = 0 and t = 15. C, plot of group data showing the effect of 0.1 μm KA on E
GABA over time. D, group data showing resting membrane potential at t = 0 and t = 15. E, group data showing driving force for Cl– at t = 0 and t = 15. F, group data showing Cl– conductance at t = 0 and t = 15. G, group data showing paired pulse ratio at t = 0 and t = 15 (n = 9 control, n = 10 KA, all experiments) (*
P < 0.05).