Figure 2.

Structure of GBA reacted with ABP 5 and adamantyl-cyclophellitol 7. (a) GBA dimer, with the cyclophellitol and linker moiety of 5 shaded in yellow and a single observed Cy5 in pink. (b) Zoomed view of a GBA monomer reacted with ABP 5. (c) Structure of GBA with adamantyl-cyclophellitol 7. The linker-adamantyl moiety of 7 is observed in slightly different positions in the two molecules of the asymmetric unit (PDB 6Q6L, SI, Figure S2), reflecting its binding through predominantly hydrophobic interactions.