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. 2019 Jan 21;29(4):1767–1777. doi: 10.1093/cercor/bhy347

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© The Author(s) 2019. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Visually evoked responses in L2/3 of V1b neurons after unilateral ON crush. (A) Top—responses as fluorescence changes of 50 neurons from a single field of view to contralateral and ipsilateral visual stimuli of 16 directions; the same field of view was imaged before (control) and after ON crush. Bottom—examples of mean Ca²⁺ traces of 4 individual neurons to contralateral and ipsilateral stimulation. Cells 1 and 2 were recorded before and cells 3 and 4 after ON crush. Left panel column shows responses at baseline (control) and right panel data from the same animal 7 days after ON crush. ODI, ocular dominance index; red, contralateral; blue, ipsilateral. (B) Quantification of overall neuronal responsiveness (nonresponsive, binocular only, contralateral only, ipsilateral only) to visual stimuli after the ON crush (B, n = 1856 neurons, 11 mice; 2 d, n = 499 neurons, 4 mice; 7d, n = 1344 neurons, 8 mice; 14d, n = 1337 neurons, 8 mice; B vs. all post crush time points, ***P < 0.001, Chi-square test). (C) The distribution of each of the visual responsive fractions after the ON crush. Data are presented as median, hinges—IQR, whiskers—min/max (B, 11 mice; 2 d, 4 mice; 7 d, 8 mice; 14 d, 8 mice; contralateral fractions at B vs. 7 d, **P = 0.0037, B vs. 14 d **P = 0.0013). (D) Bee swarm plot (median and IQR) and (E) frequency distribution of ODI values of all visually responsive neurons in L2/3 V1b neurons after the ON crush (B vs. 2 d, **P = 0.0017, B vs. 7 d and B vs. 14 d, ***P < 0.001). (C–E) Kruskal–Wallis test with Dunn’s post hoc test. (F) Mean response amplitudes of contralateral and ipsilateral responsive neurons after the ON crush and (G) cumulative distribution of ipsilateral response amplitudes (contra B vs. 7d, ***P < 0.001; ipsi B vs. 7 d and B vs. 14 d, ***P < 0.001; Kruskal–Wallis test with Dunn’s post hoc test; B contra vs. B ipsi, ***P < 0.001; Mann Whitney test). (F) Data are presented as box plots with median (hinges—IQR, whiskers—min/max). (F, G) B, contra n = 629 neurons, ipsi n = 528 neurons, 11 mice; 2d, contra n = 30 neurons, ipsi n = 39 neurons, 4 mice; 7d, contra n = 127 neurons, ipsi n = 304 neurons, 8 mice; 14d, contra n = 108 neurons, ipsi n = 289 neurons, 8 mice.