Table 1.
DNA repair proteins targeted for oxidation regulation.
| Name of protein |
Pathway | Potential target site |
Effect on activity | Reference |
|---|---|---|---|---|
| ATM | DSB repair | C-terminal Kinase domain | Activate alternate function | [66, 73-75] |
| XRCC3 | DSB repair, HDR | C86, C328 | Inhibit DNA synthesis | [76] |
| Ku | DSB repair, NHEJ | C-terminus | Reduced DNA binding, inhibit repair | [67] |
| DNA-PKcs | DSB repair, NHEJ | Unknown | Activation or Inhibition, depending on exposure | [77] |
| MGMT | Direct reversal, MGMT | Cys145 | Inhibition of activity and protein degradation | [78, 79] |
| AAG | BER | Cys167 | Decrease specificity, increase activity | [80] |
| OGG1 | BER | Cys, unknown | Inhibition of activity | [70, 81] |
| APE1 | BER | Cys65, Cys99 | Alter localization; reduced DNA binding | [82, 83] |
| PARP1 | BER | Zinc finger domain | Reduced DNA binding | [84, 85] |
| XRCC1 | BER | Cys12, Cys20 | Increased affinity to polβ | [86] |