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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: Mutagenesis. 2015 May 22;31(3):287–296. doi: 10.1093/mutage/gev039

Table 3.

The benchmark doses (BMD) producing a 10%, 50%, 100%, 200% and 300% increase in the background frequency (BMD10–300) for the six dose responses and their lower limits (BMDLs)

Chemical S9 Model 10%
 50%
 100%
 200%
 300%
BMDL10 BMD10 BMDL50 BMD50 BMDL100 BMD100 BMDL200 BMD200 BMDL300 BMD300
4-ABP + exponential 2.25 2.65 9.60 11.30 16.30 19.30 25.89 30.53 32.67 38.52
BaP + exponential 0.17 0.19 0.72  0.81  1.22  1.38  1.94  2.19  2.45  2.77
CdCl2 − polynomial 0.12 0.27 0.25  0.38  0.35  0.46  0.47  0.59  0.57  0.69a
CdCl2 + exponential 0.26 0.29 1.11  1.23  1.89  2.11  3.00  3.34  3.79  4.22a
MeIQ + liner 0.48 0.84 2.40  4.20  4.81  8.40  9.60 16.81 14.41 25.22
NNK + exponential 2.01 2.98 10.26 15.28 21.09 31.66 44.75 68.38 71.68 112.12
Fold changeb 19 16 41 40 60 69 95 116 126 163
a

For CdCl2 both with and without S9, the BMD300 is beyond the range of the actual data (4 and 0.6 μM, respectively).

b

The ratio of the greatest value to the least value in each column.