Table 5.
In vitro drug release characteristics, including kinetic parameters (nr and kr) of THP from IPC and graft copolymers at 37 °C and pH 2.2.
| Sample | Maximum Amount Released (%) | teq. (min) | t1/2r (min) | n r | R nr | kr·103 (min−1) | R kr |
|---|---|---|---|---|---|---|---|
| IPC 72/28 | 52.40 ± 2.62 | 77.6 ± 3.88 | 25.4 ± 1.27 | 1.41 ± 0.07 | 0.98 | 10.0 ± 0.50 | 1.00 |
| C25 | 56.10 ± 2.80 | 302.2 ± 15.11 | 73.5 ± 3.67 | 0.72 ± 0.03 | 0.96 | 12.4 ± 0.62 | 0.97 |
| C43 | 56.30 ± 2.81 | 271.4 ± 13.57 | 82.9 ± 4.14 | 1.01 ± 0.05 | 0.96 | 7.6 ± 0.38 | 0.97 |
| C68 | 52.40 ± 2.62 | 235.4 ± 11.74 | 41.4 ± 2.07 | 1.80 ± 0.09 | 0.93 | 1.7 ± 0.08 | 0.97 |
teq—time to reach equilibrium; t1/2r—time to release a half of drug quantity.