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Pharmacokinetic parameters obtained for raw theophylline and theophylline-loaded matrices.
| Parameter | THP | IPC 72/28 | C68 |
|---|---|---|---|
| tmax (h) | 1.03 ± 0.05 | 2.90 ± 0.14 | 3.90 ± 0.19 |
| t½ (h) | 2.50 ± 0.12 | 7.00 ± 0.35 | 12.0 ± 0.60 |
| Cmax (μg/mL) | 7.10 ± 0.35 | 3.11 ± 0.15 | 13.94 ± 0.69 |
| AUC0–72 (μg h/mL) | 38.52 ± 1.92 | 22.94 ± 1.14 | 67.43 ± 3.30 |
| Relative bioavailability (%) | - | 59.55 ± 2.97 | 175.00 ± 8.75 |
