Table 2.
Frequency of treatment changes and switches between VPS and LTG.
| Treatment changes | LTG (n = 193) | VPS (n = 194) | Total (n = 387) |
|---|---|---|---|
| Initial treatment failure (first of any treatment change) | 74 (37%) | 59 (30%) | 133 (34%) |
| Treatment changes due to ISC alone (TF1) | 52 | 26 | |
| Treatment changes due to ISC or personal choice (TF2) | 55 | 29 | |
| All treatment changes (due to ISC, personal choice or UAEs) (TF3) | 74 | 59 | |
| Switches (between LTG and VPS) (Sw3) | 59 (30%) | 34 (17%) | 93 (24%) |
| Indirect switch | 24 (12%) | 16 (8%) | 40 (10%) |
| Direct switch | 35 (18%) | 18 (9%) | 53 (13%) |
| Direct switches due to ISC alone (Dir1) | 25 | 9 | |
| Direct switches due to ISC or personal choice (Dir2) | 25 | 11 | |
| All direct switches (due to ISC, personal choice or UAEs) (Dir3) | 35 | 18 |
UAE: unacceptable adverse effect; ISC: inadequate seizure control; LTG: lamotrigine; VPS: sodium valproate.