Meyer 2017 (PROVE).

Study name	Long‐term Prophylaxis of Venous Thromboembolism with low‐molecular‐weight heparin in patients with metastatic lung cancer
Methods	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Outcomes Assessor Primary Purpose: Prevention
Participants	Adult patients aged ≥ 18 years with stage IV lung cancer and elevated D‐dimer
Interventions	Intervention: Tinzaparin sodium subcutaneous tinzaparin 4,500 IU once daily for six months. Control: No intervention‐ usual care
Outcomes	All VTE events (symptomatic and asymptomatic PE and DVT) Major bleeding Death
Starting date	April 2017
Contact information	Guy Meyer, MD +31 156 093461 guy.meyer@aphp.fr
Notes	Status as of August 2017: This study is not yet open for participant recruitment.