Table 3.
Results from analysis of pathway overrepresentation
| Pathway | Total No. of Metabolites in Both Studies | No. of Metabolites Associated with Proteinuria | Fisher Exact P Value | Permutation P Value |
|---|---|---|---|---|
| Phosphatidylethanolamine (PE) | 6 | 6 | 4.5×10−7 | 0.01 |
| Phosphatidylinositol (PI) | 5 | 3 | 0.006 | 0.04 |
| Phosphatidylcholine (PC) | 13 | 4 | 0.02 | 0.07 |
| Ceramides | 4 | 2 | 0.04 | 0.07 |
| Sterol | 4 | 2 | 0.04 | 0.03 |
| Chemical | 16 | 4 | 0.05 | 0.07 |
| Lysophospholipid | 25 | 5 | 0.07 | 0.15 |
| Vitamin A metabolism | 1 | 1 | 0.09 | 0.10 |
| Mevalonate metabolism | 1 | 1 | 0.09 | 0.09 |
| Pantothenate and CoA metabolism | 1 | 1 | 0.09 | 0.08 |
| Vitamin B6 metabolism | 1 | 1 | 0.09 | 0.11 |
| Purine metabolism, adenine containing | 6 | 2 | 0.10 | 0.43 |
| Tryptophan metabolism | 21 | 4 | 0.10 | 0.13 |
| Purine metabolism, guanine containing | 2 | 1 | 0.17 | 0.17 |
| Pentose metabolism | 3 | 1 | 0.25 | 0.22 |
| Ascorbate and aldarate metabolism | 3 | 1 | 0.25 | 0.20 |
| Plasmalogen | 11 | 2 | 0.26 | 0.41 |
| Leucine, isoleucine and valine metabolism | 27 | 4 | 0.30 | 0.26 |
| Histidine metabolism | 12 | 2 | 0.30 | 0.30 |
| Polyamine metabolism | 5 | 1 | 0.38 | 0.36 |
| Glycolysis, gluconeogenesis, and pyruvate metabolism | 5 | 1 | 0.38 | 0.38 |
| Alanine and aspartate metabolism | 6 | 1 | 0.44 | 0.40 |
| Phenylalanine metabolism | 6 | 1 | 0.44 | 0.45 |
| Pyrimidine metabolism, uracil containing | 7 | 1 | 0.49 | 0.50 |
| Purine metabolism, (hypo)xanthine/inosine containing | 7 | 1 | 0.49 | 0.50 |
| Food component/plant | 30 | 1 | 0.51 | 0.92 |
| Glycine, serine, and threonine metabolism | 8 | 1 | 0.54 | 0.48 |
| Sphingolipid metabolism | 22 | 1 | 0.71 | 0.59 |
| Urea cycle; arginine and proline metabolism | 15 | 1 | >0.99 | 0.67 |
| Fatty acid, dicarboxylate | 16 | 1 | >0.99 | 0.65 |