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. 2019 Mar 4;2019(3):CD005139. doi: 10.1002/14651858.CD005139.pub4

2. Treatment groups in included trials.

Study
Treatment period
Intervention 1 Intervention 2 Intervention 3 Intervention 4
Pegaptanib vs control
VISION 2004
2 years; re‐randomized at end of first year
0.3 mg pegaptanib every 6 weeks 1.0 mg pegaptanib every 6 weeks 3.0 mg pegaptanib every 6 weeks Sham every 6 weeks
Ranibizumab vs control
ANCHOR 2006
2 years
0.3 mg ranibizumab monthly plus sham verteporfin PDT 0.5 mg ranibizumab monthly plus sham verteporfin PDT Sham intravitreal injection plus verteporfin PDT
MARINA 2006
2 years
0.3 mg ranibizumab monthly 0.5 mg ranibizumab monthly Sham intravitreal injection monthly
PIER 2008
2 years
0.3 mg ranibizumab monthly for 3 months, then every 3 months 0.5 mg ranibizumab monthly for 3 months, then every 3 months Sham intravitreal injection monthly for 3 months, then every 3 months
Bevacizumab vs control
ABC 2010
1 year
1.25 mg bevacizumab given first 3 injections every 6 weeks, then as needed Standard therapy (0.3 mg pegaptanib every 6 weeks, verteporfin PDT, or sham injection)
Sacu 2009
1 year
1.0 mg bevacizumab monthly for 3 months, then as needed Verteporfin PDT plus same day 4 mg triamcinolone acetonide
Bevacizumab vs ranibizumab
CATT 2011
2 years; re‐randomized at end of first year
1.25 mg bevacizumab monthly for 1 year; at 1 year, re‐randomization to ranibizumab monthly or variable dosing 0.5 mg ranibizumab monthly for 1 year; at 1 year, re‐randomization to ranibizumab monthly or variable dosing 1.25 mg bevacizumab as needed after first injection for 2 years 0.5 mg ranibizumab as needed after first injection for 2 years
IVAN 2013
2 years; ongoing
1.25 mg bevacizumab monthly for 2 years 0.5 mg ranibizumab monthly for 2 years 1.25 mg bevacizumab monthly for 3 months, then as needed in 3‐month cycles 0.5 mg ranibizumab monthly for 3 months, then as needed in 3‐month cycles
Biswas 2011
 18 months 1.25 mg bevacizumab monthly for 3 months, then as needed 0.5 mg ranibizumab monthly for 3 months, then as needed
BRAMD 2016
 1 year 1.25 mg bevacizumab monthly for 1 year 0.5 mg ranibizumab monthly for 1 year
GEFAL 2013
1 year
1.25 mg bevacizumab; maximum of 1 injection per month 0.5 mg ranibizumab; maximum of 1 injection per month
LUCAS 2015
1 year
1.25 mg bevacizumab; treat and extend protocol 0.5 mg ranibizumab; treat and extend protocol
MANTA 2013
 1 year 1.25 mg bevacizumab monthly for 3 months, then as needed 0.5 mg ranibizumab monthly for 3 months, then as needed
SAVE‐AMD 2017
1 year
1.25 mg bevacizumab at day 1 and at week 4, then as needed 0.5 mg ranibizumab at day 1 and at week 4, then as needed
Scholler 2014
1 year
1.25 mg bevacizumab for 3 months, at 30‐day intervals, then as needed 0.5 mg ranibizumab for 3 months, at 30‐day intervals, then as needed
Subramanian 2010
1 year
0.05 mL bevacizumab monthly for 3 months, then as needed 0.05 mL ranibizumab monthly for 3 months, then as needed

PDT: photodynamic therapy.