Figure 1.

Down-regulation of METTL3 inhibited cell proliferation of human gastric cancer cells.

shMETTL3 interference plasmid was constructed and introduced into human gastric cancer cells. A scrambled shRNA was used as a negative control (NC) in all experiments. (A) The interference efficiency of METTL3 was detected by using RT-qPCR; (B) Cell proliferation of AGS and MKN45 was detected by CCK8 assay; (C) and (D) Colony formation of AGS and MKN45 cells after transfection with shMETTL3 or shNC. All experiments were performed in triplicate. *P<0.05.