Table 2.
Outcomes
| Outcomes | Total (44) | Liberal (21) | Restrictive (23) | p value |
|---|---|---|---|---|
| Hemoglobin concentration, g/dL | ||||
| 14-day, g/dL | 8.8 ± 1.2 | 9.3 ± 1.3 | 8.4 ± 1.0 | < 0.01 |
| Hospital admission | 12.3 ± 2.0 | 12.0 ± 2.3 | 12.5 ± 1.8 | 0.53 |
| ICU admission | 10.2 ± 1.4 | 10.1 ± 1.2 | 10.3 ± 1.6 | 0.55 |
| Pre-randomization | 8.1 ± 0.8 | 7.9 ± 0.6 | 8.2 ± 1.0 | 0.34 |
| Patients transfused | 34 (77) | 21 (100) | 13 (57) | < 0.01 |
| Total transfused RBC units | 101 | 66 | 35 | 0.02 |
| RBC units per patient | 2.3 ± 1.8 | 3.1 ± 1.6 | 1.5 ± 1.7 | < 0.01 |
| Other blood products | 0 | 0 | 0 | 0 |
| Mortality | ||||
| ICU death | 8 (18) | 1 (5) | 7 (30) | 0.05 |
| In-hospital death | 8 (18) | 1 (5) | 7 (30) | 0.05 |
| Discharge functional outcome (GOS) | ||||
| Ordinal | 0.06 | |||
| 1 – Death | 8 (18) | 1 (5) | 7 (30) | |
| 2 – Vegetative state | 7 (16) | 3 (14) | 4 (17) | |
| 3 – Severe disability | 6 (14) | 4 (19) | 2 (9) | |
| 4 – Moderate disability | 16 (36) | 9 (43) | 7 (30) | |
| 5 – Good recovery | 7 (16) | 4 (19) | 3 (13) | |
| Dichotomous | 0.22 | |||
| Unfavorable (GOS–3) | 21 (48) | 8 (38) | 13 (57) | |
| Favorable (GOS 4–5) | 23 (52) | 13 (62) | 10 (44) | |
| Length of stay, days | ||||
| ICU | 17 [10–28] | 21 [9–30] | 16 [13–18] | 0.35 |
| Hospital | 39 [23–66] | 35 [21–63] | 42 [23–76] | 0.59 |
| Functional outcome (GOS) at 6 months | ||||
| Ordinal | 0.06 | |||
| 1 – Death | 9 (21) | 2 (10) | 7 (30) | |
| 2 – Vegetative state | 5 (11) | 2 (10) | 3 (13) | |
| 3 – Severe disability | 7 (16) | 4 (19) | 3 (13) | |
| 4 – Moderate disability | 8 (18) | 3 (14) | 5 (22) | |
| 5 – Good recovery | 15 (34) | 10 (48) | 5 (22) | |
| Dichotomous | 0.20 | |||
| Unfavorable (GOS–3) | 21 (48) | 8 (38) | 13 (57) | |
| Favorable (GOS 4–5) | 23 (52) | 13 (62) | 10 (44) | |
Values are expressed as the mean ± standard deviation, median [25th–75th percentiles] or number (percentage)
ICU intensive care unit, RBC red blood cell, GOS Glasgow Outcome Scale