Table 2.
Subgroup analysis based on medication type
| Indicator | Vasopressin | Vasopressin’s analogues |
|---|---|---|
| ICU length of stay (MD) | − 0.17 (95% CI − 0.98–0.63, P = 0.67, I2 = 0%) | 0.03 (95% CI − 0.87–0.93, P = 0.94, I2 = 24%) |
| Duration of MV (MD) | − 1.00 (95% CI −2.39-0.39, P = 0.16)* | − 0.50 (95% CI − 1.57–0.57, P = 0.36, I2 = 63%) |
| Total adverse events (RR) | 1.13 (95% CI 0.83–1.53, P = 0.43, I2 = 0%) | 1.20 (95% CI 0.52–2.74, P = 0.67, I2 = 79%) |
| Digital ischemia (RR) | 3.33 (95% CI 1.39–7.95, P < 0.001, I2 = 0%) | 6.06 (95% CI 2.97–12.37, P < 0.001, I2 = 68%) |
| Cardiovascular events (RR) | 0.93 (95% CI 0.51–1.69, P = 0.80, I2 = 27%) | 0.84 (95% CI 0.24–2.99, P = 0.79, I2 = 0%) |
| Arrhythmia (RR) | 0.99 (95% CI 0.51–1.91, P = 0.98, I2 = 15%) | 0.57 (95% CI 0.29–1.15, P = 0.12, I2 = 35%) |
| Mesenteric ischemia (RR) | 0.77 (95% CI 0.38–1.53, P = 0.45, I2 = 0%) | 1.22 (95% CI 0.26–5.64, P = 0.80, I2 = 42%) |
| Diarrhea (RR) | 0.98 (95% CI 0.06–15.58)* | 1.64 (95% CI 0.05–54.19, P = 0.78, I2 = 71%) |
| Cerebrovascular events (RR) | 0.98 (95% CI 0.06–15.58, P = 0.99)* | 2.00 (95% CI 0.09–46.68, P = 0.67)* |
| Hyponatremia (RR) | 2.31 (95% CI 0.35–15.09, P = 0.38, I2 = 0%) | 1.39 (95% CI 0.78–2.49, P = 0.26)* |
RR relative risk, MD mean difference, CI confidence interval, ICU intensive care unit, MV mechanical ventilation
*Only one study