Fig. 5.

miR-30c inhibits the migration and invasion ability of gastric cancer cells and is associated with patients’ survival. a and d Correlation analysis showed that both miR-30c-1-3p and miR-30c-2-3p expressions were inversely correlated with GAGE7B expression (Spearman r = − 0.247 and - 0.387, respectively). b and c In patients’ survival analysis, low expression of miR-30c-1-3p was associated with patients’ poor OS (b) and DFS (c) (Log-rank test, P = 0.044 and P = 0.015, respectively). e and f. The association between miR-30c-2-3p expression and patients’ OS (e) and DFS (f) was simultaneously analyzed and the results suggested that low expression of miR-30c-2-3p was also associated with poor patients’ OS (Log-rank test, P = 0.015). g and h The migration and invasion ability of MKN45 and BGC823 cells was significantly inhibited upon overexpression of miR-30c-1-3p and miR-30c-2-3p (g and h). (t-test, **P < 0.01, *P < 0.05). i and j. The enhanced migration and invasion ability of MKN45 (i) and BGC823 (j) cells was observed in miR-30c-1-3p or miR-30c-2-3p knockdown group. (t-test, *P < 0.05,**P < 0.01)