Table 2.
Demographic characteristics of 10 islet transplant recipients (5 islet transplant alone and 5 islet after kidney transplants).
| Subject no. | Islet alone (ITA) or islet after kidney (IAK) | Immunosuppressive regimen | Number of infusions | Total number of IEQ | Total IEQ/kg | Obtained insulin independence? | Insulin independent at 1 year post-final transplant? | Number of days insulin independent† | Units of insulin
required (12 months post-initial transplant) |
Units of Insulin
required (12 months post-final transplant) |
Number of severe hypoglycaemic episodes at 1 year post-initial transplant | HgbA1c | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pretransplant | 1 year post-initial transplant | 3 months post-final transplant | 6 months post-final transplant | 9 months post-final transplant | 12 months post-final transplant | ||||||||||||
| i | ITA | Dac, Tac., Sir. | 3 | 1 269 000 | 20 466 | Y | Y | 1790 | 13 | 0 | 0 | 5.9 | 5.3 | 5.3 | 6.7 | 7.4 | ND |
| 2* | ITA | Dac, Tac., MMF | 2 | 834 000 | 11 440 | N | N | 0 | 24 | * | * | 8.9 | * | 7.9 | * | * | * |
| 3 | IAK | Dac, Tac., Sir MMF | 3 | 1 178 659 | 17 886 | Y | Y | 372 | 0 | 0 | 0 | 7.5 | 4.5 | <4 | 4.4 | 4.6 | 4.8 |
| 4 | ITA | Dac, Tac., Sir | 3 | 2 548 932 | 31 810 | N | N | 0 | 32 | 25 | 0 | 7.4 | 6.7 | 5.8 | 6.8 | 6.9 | 6.9 |
| 5** | ITA | Dac, Tac., Sir | 2 | 2 020 000 | 27 419 | Y | N | 270 | 0 | 20 | 0 | 8 | 5.6 | 5.8 | 5.6 | 6.5 | 6.3 |
| 6 | ITA | Dac, Tac., Sir MMF | 2 | 1 782 111 | 25 817 | Y | Y | 1596 | 0 | 0 | 0 | 7.3 | 5.6 | 5.2 | 5.6 | 5.1 | 5.6 |
| 7 | ITA | Dac, Tac., Sir | 3 | 2 032 850 | 29 614 | Y | N | 63 | 10 | 15 | 0 | 7.1 | 7.4 | 7.0 | 7.4 | 8 | 8.4 |
| 8 | IAK | Dac, Tac., Sir Myfortic | 2 | 1 334 700 | 25 430 | Y | Y | 1465 | 0 | 0 | 0 | 7.7 | 5.3 | 6 | 6.1 | 5.3 | 5.3 |
| 9 | IAK | Dac, Tac., Sir MMF | 2 | 1 061 310 | 19 187 | Y | Y | 631 | 0 | 0 | 0 | 6.7 | 5.9 | 5.8 | 6.0 | NA | 5.9 |
| 10 | IAK | Dac, Tac., Sir Dac, Tac., Sir M | 2 | 994 350 | 18 397 | Y | Y | 521 | 0 | 0 | 0 | 7.5 | 5.8 | 6.1 | 5.7 | 5.8 | 5.6 |
Patients received an average of 22 746 ± 6289 IEQ/kg body weight. Eight patients achieved insulin independence. Six of 10 patients remained insulin independent > 1 year. Six patients required two infusions and the remaining four patients received three infusions.
Subject no. 2 withdrew from the study.
Patient is waiting for third transplant.
As of 2 May 2010.