Table 3.
Metabolic variables pretransplant and 12 months post-islet transplant compared to non-diabetic controls matched by gender, age and BMI.
| Measure | Pre-Tx | 12 months post-Tx | p (pre vs. post) | NDC | p (pre vs. NDC) | p (post vs. NDC) |
|---|---|---|---|---|---|---|
| BMI (kg/m2) | 23.7 ± 0.7 | 22.5 ± 0.7 | 0.29 | 23.0 ± 1.3 | 0.65 | 0.74 |
| Basal glucose (mmol/1) | 5.5 ± 0.3 | 5.3 ± 0.4 | 0.66 | 4.5 ± 0.1 | 0.07 | 0.21 |
| Basal insulin (pmol/l) | 19 ± 9 | 17 ± 2 | 0.81 | 13.3 ± 6 | 0.67 | 0.38 |
| Kg | 0.96 ± 0.03 | 1.25 ± 0.09 | 0.05 | 1.59 ± 0.15 | 0.004 | 0.08 |
| Si [× 10−5/min/(pmol/l)] | 3.5 ± 0.8 | 9.6 ± 1.3 | 0.003 | 10.8 ± 0.6 | 0.0004 | 0.58 |
| Sg (× 10−2/min) | 0.74 ± 0.24 | 1.28 ± 0.22 | 0.12 | 1.27 ± .022 | 0.21 | 0.97 |
| BIE (× 10−2/min) | 1.53 ± 0.63 | 1.69 ± 0.23 | 0.80 | 1.41 ± 0.55 | 0.90 | 0.59 |
| GEZI (×10−2/min) | −0.80 ± 0.75 | −0.41 ± 0.26 | 0.59 | −0.14 ± 0.36 | 0.58 | 0.60 |
| AIRg (pmol/l min) | 25 ± 61 | 637 ± 251 | 0.06 | 1418 ± 235 | 0.0001 | 0.08 |
| ACRg (nmol/l min) | 0 ± 0 | 1.6 ± 0.6 | 0.05 | 7.0 ± 1.2 | 0.0001 | 0.001 |
| DI (min) | 0.0001 ± 0.0002 | 0.058 ± 0.021 | 0.04 | 0.156 ± 0.034 | 0.0002 | 0.04 |
BIE, basal insulin effect; BMI, body mass index; GEZI, glucose effectiveness at zero insulin; DI, disposition index.