White 2012

Trial name or title	Graded Exercise Therapy guided SElf‐help Treatment (GETSET) for patients with chronic fatigue syndrome/myalgic encephalomyelitis: a randomised controlled trial in secondary care (GETSET)
Methods	Randomised interventional trial
Participants	Inclusion Patients attending 2 CFS/ME specialist clinics in London Patients receiving a diagnosis of CFS/ME from a specialist doctor and going onto a waiting list for clinic treatment Patients 18 years of age or older Speak and read English adequately to provide informed consent and read the guided support booklet Target gender: male and female Lower age limit: 18 years Exclusion Not receiving a diagnosis of CFS/ME Co‐morbid condition that requires that exercise be performed only in the presence of a doctor Younger than age 18 Active suicidal thoughts
Interventions	Guided support, a copy of the GETSET booklet, a 30‐minute consultation face‐to‐face by Skype or by telephone, 3 further Skype telephone contacts Intervention over 9 weeks: follow‐up length: 3 month(s); study entry: single randomisation only
Outcomes	Primary: SF‐36 physical function subscale (SF‐36PF) measured 12 weeks from randomisation Secondary: Clinical Global Impression Change Scale (CGI) score measured 12 weeks from baseline
Starting date	16/05/2012
Contact information	Prof PD White; p.d.white@qmul.ac.uk
Notes	http://www.controlled‐trials.com/ISRCTN22975026/GETSET

ANOVA, analysis of variance.

CFS, chronic fatigue syndrome.

CGI, Clinical Global Impression scale.

CIS, Checklist of Individual Strength.

COPM, Canadian Occupational Performance Measure.

ELISA, enzyme‐linked immunosorbent assay.

EuroQol 6‐D: Short Form 6‐D of the standard measure of health outcomes of the EuroQol Group.

GE, Graded exercise.

ICF, idiopathic chronic fatigue.

IFN, interferon.

IL, interleukin.

ITE, intermittent exercise training.

MI, motivational interviewing.

MRT, multi‐disciplinary rehabilitation therapy.

NK, natural killer cell.

RER, respiratory exchange ratio.

RPE, rating of perceived exertion.

SC, standard care.

SS, steady state.

VO₂, oxygen consumption