Table 2.

Performances comparison with different combinations of multi-omics data by pairwise paired t-test, according to concordance index among 5-folds cross-validation results.

Pairwise paired T-test
		Set 2
		ii		iii		iv		v		vi
		t	P	t	P	t	P	t	P	t	P
Set 1	i	−0.784	0.477	−0.676	0.536	−0.832	0.452	−2.928	0.043*	−3.315	0.030*
	ii	-	-	0.406	0.705	−0.487	0.652	−0.092	0.931	−0.652	0.550
	iii	–	–	–	–	0.247	0.817	−5.804	0.004*	−2.710	0.054
	iv	–	–	–	–	–	–	−4.168	0.014*	−3.603	0.023*
	v	–	–	–	–	–	–	–	–	−1.529	0.201

Note that a negative t-statistic indicated set 1 worse than set 2 in terms of performances. Multi-omics dataset applied as inputs: (i) mRNA-seq data (mRNA) (57 features); (ii) miRNA-seq data (miRNA) (12 features); (iii) integration of mRNA and miRNA (69 features); (iv) integration of mRNA, miRNA, copy number burden (CNB), and tumor mutation burden (TMB) (71 features); (v) integration of mRNA, miRNA, and demographical and clinical (diagnosis age, ER status, PR status) data (72 features); (vi) integration of mRNA, miRNA, CNB, TMB, and demographical and clinical (diagnosis age, ER status, PR status) data (74 features).

t-denotes the pairwise paired Student's t-test statistic, P denotes the p-value obtained. P-value < 0.05 are considered to be significant and indicated with * symbol.