Table 4.

Top features that reduced the concordance indices.

Ranks	Age group 26–50		Age group 51–70		Age group 71–90
	Feature names	Concordance index changed (median)	Feature names	Concordance index changed (median)	Feature names	Concordance index changed (median)
1	PR status	–0.0247	ER status	–0.0807	Module 11	–0.0323
2	Module 1	0	Module 13	−0.0221	Module 1	–0.0233
3	Module 2	0	Module 4	−0.0185	Module 29	–0.0233
4	Module 3	0	Module 5	−0.0150	Module 35	–0.0233
5	Module 4	0	Diagnosis age	−0.0150	Module 4	–0.0222

Experiments performed separately with three age groups: 26–50 group; 51–70 group; 71–90 group, with integrating all omics data (integration of mRNA, miRNA, CNB, TMB, diagnosis age, ER status, PR status). Detailed feature rankings are in Figures S5–S7. The bold values are of our interests and are being discussed.