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. 2019 Mar 8;25:1769–1779. doi: 10.12659/MSM.914916

Figure 4.

Figure 4

The effects of remote ischemic conditioning (RIC) on cardiac hemodynamic function and mitochondrial respiratory function in the rat model of acute myocardial infarction (AMI). (A–D) The myocardial concentrations of mitochondrial respiratory chain complexes 1, 2, 3, and 4. (E) The apoptosis index of the ischemia area for the three groups, the sham group, the AMI group, and the RIC group. (F) The serum concentrations of caspase-3 in each of the three rat groups. (G–I) The expression of Bcl-2 and Bax protein, and the ratio of Bcl-2/Bax in each group. (J) Myocardial cell apoptosis determined by TUNEL staining in rats after AMI. Scale bar=200 μm. (K–L) The levels of ATP and inducible nitric oxide synthase (iNOS) in each group. (M) Western blot assay for the protein levels of caspase-3, Bcl-2, and Bax in each group. * P<0.05, ** P<0.01 vs. the AMI group; # P<0.05, ## P<0.01 vs. the sham group. Data are presented as the mean ± standard deviation (SD) (n=24) (8 rats per session).